Bupropion/Naltrexone

How it works?

• Bupropion: An antidepressant (often used for depression and smoking cessation) that affects dopamine and norepinephrine, reducing appetite and increasing energy.

• Naltrexone: Typically used to treat alcohol and opioid dependence, it may help regulate food cravings and reward-driven eating.

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How Much Weight Can You Lose?

• Studies show an average of 5-10% body weight loss over several months.

• Studies suggest that people taking bupropion-naltrexone alongside diet and exercise can lose 5–10% of their body weight within a year. Results vary.

• Weight loss is more significant when combined with a healthy diet and exercise.

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Who Might Benefit?

• People who are overweight or obese, especially those with depression or emotional eating habits.

• Individuals trying to quit smoking who also want to lose weight (bupropion is used as a smoking cessation aid).

• Those who need an alternative to weight loss medications that cause drowsiness or fatigue (bupropion can increase energy).

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Common Side Effects

• Insomnia (take it in the morning to avoid this)

• Dry mouth

• Increased heart rate & blood pressure

• Anxiety or jitteriness

• Headaches & dizziness

• Seizure risk (rare, but higher in people with a history of seizures or eating disorders like bulimia)

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Should You Take Bupropion for Weight Loss?

• It can be effective, especially for those with depression or food cravings.

• Works best in combination with a structured weight loss plan.

• Not suitable for people with a history of seizures, eating disorders, or uncontrolled high blood pressure, pregnant or breastfeeding, Individuals on opioids (naltrexone blocks opioid effects).

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