Sildenafil is an FDA-approved oral medication used to treat erectile dysfunction (ED). It works by increasing blood flow to the penis, helping men achieve and maintain an erection with sexual stimulation. How it works: Sildenafil relaxes blood vessels by inhibiting the PDE-5 enzyme, improving circulation during arousal. Onset & duration: Starts working in 30–60 minutes Effects last about 4–6 hours Best taken on an empty stomach Who it’s for: Men experiencing difficulty getting or maintaining an erection due to blood flow, stress, or mild to moderate ED. Common side effects: Headache, flushing, nasal congestion, upset stomach, or dizziness (usually mild and temporary). Important safety note: Sildenafil should not be used with nitrate medications or in certain heart conditions. Prescription required.

Tadalafil is an FDA-approved oral medication used to treat erectile dysfunction (ED). It improves blood flow to help achieve and maintain an erection with sexual stimulation. How it works: Tadalafil inhibits the PDE-5 enzyme, allowing blood vessels to relax and increase circulation. Onset & duration: Starts working in 30–60 minutes Lasts up to 36 hours Can be taken daily or as needed Who it’s for: Men who prefer longer-lasting flexibility or more spontaneous sexual activity. Common side effects: Headache, flushing, nasal congestion, muscle or back pain, indigestion. Important safety note: Do not use with nitrate medications or in certain heart conditions. Prescription required.